Analgesic Activity of the 4-Anilidopiperidines Utilizing Isomeric N-Substituted 3-(Propanani1ido)nortropane Analogues

of 1.3 mg/kg for 7 days in combination with 5 (mg/kg)/day of chloroquine. Antileishmanial Test Method. The antileishmanial activity of 2d was determined in golden hamsters by the method of Hanson et Male golden hamsters were inoculated intracardially with lo7 amastigotes of the Khartoum strain of Leishmania donovani. Administration of the drug was begun 3 days after inoculation and was continued twice daily for 4 days. On day 6 the hamsters were sacrificed and the ratio of the number of amastigotes per host liver cell nucleus was determined. Comparison was made of the suppressive effects of the test compound to that of the reference compound, glucantime (N-methylglucamine antimonate), and a glucantime index, G, was calculated using the formula: G = dose (SD,) of glucantime/dose (SD,) of test drug. Acknowledgment. The authors gratefully acknowledge the interest and assistance of Col. David E. Davidson, Division of Experimental Therapeutics, Walter Reed Army Institute of Research. Data on efficacy in the rhesus monkey tissue schizonticidal model was provided by Dr. John Brown and Dr. Frank Chapple of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. Antileishmanial testing was performed by Dr. William Hanson, University of Georgia School of Veterinary Medicine, Athens, Ga.